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Summarized Content:

Therefore to more precisely assess potential genetic contributions to human longevity from genes linked to IIS signaling we chose a large homogeneous long-lived population of men well-characterized for aging phenotypes and we performed a nested-case control study of 5 candidate longevity genes... Genetic variation within the FOXO3A gene was strongly associated with human longevity...


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longevity, human, gene, genetic, homozygou, population, signaling, study, phenotype, iis, aging, pathway, contribution, precisely, conserved, insulin, challenge, lack, increasing, nested-case, candidate, phenotyping, biological, evolutionarily, allele, foxo3a, men, complex, long-lived, scarce, influence


Original Content

http://www.pnas.org/content/105/37/13987.long (abstract only)

Human longevity is a complex phenotype with a significant familial component, yet little is known about its genetic antecedents. Increasing evidence from animal models suggests that the insulin/IGF-1 signaling (IIS) pathway is an important, evolutionarily conserved biological pathway that influences aging and longevity. However, to date human data have been scarce. Studies have been hampered by small sample sizes, lack of precise phenotyping, and population stratification, among other challenges. Therefore, to more precisely assess potential genetic contributions to human longevity from genes linked to IIS signaling, we chose a large, homogeneous, long-lived population of men well-characterized for aging phenotypes, and we performed a nested-case control study of 5 candidate longevity genes. Genetic variation within the FOXO3A gene was strongly associated with human longevity. The OR for homozygous minor vs. homozygous major alleles between the cases and controls was 2.75 (P ...



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